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Steven A. Frank , "Dynamics of Cancer: Incidence, Inheritance, and Evolution (Princeton Series in Evolutionary Biology)"
Publisher: Princeton University Press | ISBN: 0691133662 | 400 Pages | PDF | 2.8 Mb
The onset of cancer presents one of the most fundamental problems in modern biology. In Dynamics of Cancer, Steven Frank produces the first comprehensive analysis of how particular genetic and environmental causes influence the age of onset.

The book provides a unique conceptual and historical framework for understanding the causes of cancer and other diseases that increase with age. Using a novel quantitative framework of reliability and multistage breakdown, Frank unifies molecular, demographic, and evolutionary levels of analysis. He interprets a wide variety of observations on the age of cancer onset, the genetic and environmental causes of disease, and the organization of tissues with regard to stem cell biology and somatic mutation. Frank uses new quantitative methods to tackle some of the classic problems in cancer biology and aging: how the rate of increase in the incidence of lung cancer declines after individuals quit smoking, the distinction between the dosage of a chemical carcinogen and the time of exposure, and the role of inherited genetic variation in familial patterns of cancer.

This is the only book that presents a full analysis of the age of cancer onset. It is a superb teaching tool and a rich source of ideas for new and experienced researchers. For cancer biologists, population geneticists, evolutionary biologists, and demographers interested in aging, this book provides new insight into disease progression, the inheritance of predisposition to disease, and the evolutionary processes that have shaped organismal design.
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Veterans Affairs Medical Center, Augusta, GA. Reviews scientific advances in molecular genetics and biology of chronic lymphocytic leukemia. Discusses the clinical aspects, focusing on diagnosis, prognosis, treatment options, and complications. Also addresses familial and juvenile cases.
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David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.
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Emerging as an important new volume in the renowned Cancer Drug Discovery and Developmentâ„¢ series, Deoxynucleoside Analogs in Cancer Therapy expertly summarizes the current status of development and application of deoxynucleoside analogs. Authoritative up-to-date reviews are presented by scientists well known in their specific areas and all contributions include valuable sound advice on structure and topics.

Organized into several sections, the first part covers general aspects of drug uptake and metabolism and explains how novel technology has enabled a rapid expansion of this field. The second part is concerned with a number of specific drugs including cytarabine, gemcitabine, troxacitabine, clofarabine and ara-G. The final section covers pharmacokinetics, prodrugs, and specific applications such as radiosensitization, gene therapy, and the use of deoxynucleoside analogs as tracers.

Throughout Deoxynucleoside Analogs in Cancer Therapy, the focus is on novel aspects of deoxynucleoside analogs in the clinical context, as well as on unexpected targets of these compounds, such as their specific activity against cell cycle-dependent kinases or oncogenes. The wealth of information presented here can be used to design rational combinations aimed at inhibiting various cellular signaling pathways, or combining inhibition of various targets. Deoxynucleoside Analogs in Cancer Therapy has been designed specifically to facilitate such an interaction between various fields.
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Description: The Handbook on Cancer Survivorship responds to the diverse needs of survivors and their support communities by comprehensively addressing the major issues in the field, from the burden of survivorship to secondary prevention. Editor Michael Feuerstein, himself a cancer survivor, and sixty other top scientist-practitioners analyze in depth how survivors meet and manage the challenges of life after cancer, and what clinicians, researchers, and public health systems can do to ease the transition.

Advances in research and the treatment of cancer mean that more patients and their carers are asking healthcare professionals about the latest treatments and how they may be of benefit. It is essential that staff working with cancer patients understand fully how these new treatments work in order to disseminate timely and appropriate information to patients.

The application of biology to the delivery of cancer care is playing an ever-increasing role in the management of these diseases. The Biology of Cancer: Second Edition provides details of the most recent developments in cancer care and is divided into three sections:

* Understanding Cancer – examines predisposing factors to developing cancer, diagnosis and its implications on the individual and society.
* The Science of Cancer – a closer look at the cell, genetics, the immune system, tumour markers and monoclonal antibodies.
* Research and Treatment – exploring translational oncology, applying research methodology to cancer research and research ethics relating to cancer.

This fully updated edition also looks at evidence-based research that can be translated directly to patient care and gives details recent developments. Written by experienced, practicing healthcare professionals, The Biology of Cancer: Second Edition can easily be applied to patient care. It is an informative text for students, newly qualified nurses and